Protease activated receptors (PARs) and inflammatory bowel disease
| PAR1 | PAR2 |
|---|---|
| PAR1 potential target for IBD treatments | |
| Upregulated in the colon of CD and UC patients | Upregulated in the colon of UC patients |
| Activation causes colitis and increased permeability | Acute activation causes colitis but chronic systemic activation is protective |
| Activation is involved in the pathogenesis of IBD animal models | |