Table 1

Summary of changes in cancers with O⁶-methylguanine methyltransferase (MGMT) mutations

Cancer	MSI status	K-ras mutation	p53 mutation	MGMT mutation	LOH	MGMT mRNA	MGMT protein
MSI, level microsatellite instability; LOH, loss of heterozygosity.
930	High	None	None	G23D G:C>A:T	No	N/D	Undetectable
DLD1	High	G12C G:C>T:A	S241F G:C>A:T	G55C G:C>T:A	No	Mutant only	Normal
684	Stable	None	Normal	A75D G:C>T:A	No	N/D	Undetectable
1350	Low	None	Normal	A75D G:C>T:A	No	N/D	Normal
6	Low	None	R248W G:C>A:T	K104E A:T>G:C	Yes	N/D	Undetectable
SW48	High	None	R248W G:C>A:T	G156C G:C>T:A	No	Mutant only	Reduced