Characteristics of patients with chronic hepatitis B according to hepatitis B virus (HBV) genotype*
| Genotype A (n = 78) | Genotype B (n = 6) | Genotype C (n = 11) | Genotype D (n = 66) | Genotype E (n = 3) | All (n = 165) | |
|---|---|---|---|---|---|---|
| *The patient with HBV genotype G was not included in the analysis. | ||||||
| †Diagnosis of liver cirrhosis was made on liver histology. Liver histology was available in 100 patients. | ||||||
| ‡Sex distribution, age, and ALT levels were significantly different in HBV genotype B patients compared with HBV genotype A or D (all p<0.05). | ||||||
| §Perinatal infection rate was higher among patients with HBV genotypes B, C, and D compared with HBV genotype A (p<0.03). | ||||||
| HBeAg, hepatitis B e antigen; ALT, alanine aminotransferase; ND, not determined. | ||||||
| Origin (%) | ||||||
| Germany | 76 | – | 9 | 23 | – | 46 |
| Mediterranean | 6 | – | – | 63 | – | 28 |
| Eastern Europe | 14 | – | – | 11 | – | 11 |
| Asia | – | 100 | 91 | 3 | – | 11 |
| Africa | 4 | – | – | – | 100 | 4 |
| Sex (%) | ||||||
| Female | 13 | 50 | 36 | 26 | – | 21 |
| Male | 87‡ | 50‡ | 64 | 74 | 100 | 79 |
| HBeAg positive (%) | 78 | 100 | 91 | 58 | 100 | 72 |
| Age (y) | 47 (7)‡ | 27 (2)‡ | 40 (4) | 39 (14)‡ | 27 (2) | 47 (7) |
| Mode of acquisition (%) | ||||||
| Perinatal | 20§ | 67§ | 55§ | 45§ | – | 34 |
| Sexual | 15 | 16 | – | 8 | 100 | 13 |
| Transfusion | 31 | – | – | 20 | – | 22 |
| Health care | 4 | – | 9 | 6 | – | 5 |
| Other/unknown | 30 | 17 | 36 | 21 | – | 26 |
| Cirrhosis† (%) | 27 | ND | 20 | 26 | ND | 25 |
| ALT (U/l) | 96 (8)‡ | 33 (11)‡ | 104 (33) | 82 (10)‡ | 55 (22) | 86 (6) |
| DNA (pg/ml) | 590 (317) | 442 (874) | 1078 (2072) | 459 (135) | 507 (597) | 580 (212) |
| Cumulative IFN dose (MU) | 418 (21) | 552 (118) | 574 (100) | 447 (20) | 596 (144) | 450 (15) |