ICG, International Collaborative Group; CRC, colorectal cancer. |
There should be at least 3 relatives with CRC, or there should be at least 3 relatives with an HNPCC associated cancer (CRC, endometrium, small bowel, ureter, or renal pelvis); all the following should be present: |
• One should be a first degree relative of the other two |
• At least 2 successive generations should be affected |
• At least 1 CRC should be diagnosed before the age of 50 |
• Familial adenomatous polyposis should be excluded |
• Tumours should be verified by pathological examination |