Criteria for suspicion of hereditary non-polyposis colorectal cancer (HNPCC) based on ICG definition of HNPCC (Lynch syndrome)
| ICG, International Collaborative Group; CRC, colorectal cancer. |
| • Familial clustering of CRC and/or endometrial cancer (2 first degree relatives across 2 generations, with further affected second degree relatives) |
| • Associated cancers of: stomach, ovary, ureter/renal pelvis, small bowel, hepatobiliary tract, skin (sebaceous tumours) |
| • Development of cancer at an early age |
| • Development of multiple cancers, particularly multiple CRCs |
| • Proximal location of CRC |