Association between mismatch repair gene expression and family history of colorectal and extracolonic cancer based on multivariate logistic regression
| Loss of hMLH1§ | Loss of hMSH2¶ | |||||
|---|---|---|---|---|---|---|
| OR† | 95% CI† | p Value† | OR† | 95% CI† | p Value† | |
| OR, odds ratio; CI, confidence interval; CRC, colorectal cancer; FH, family history; FDR, first degree relative. | ||||||
| *FH of HNPCC spectrum extracolonic cancer. | ||||||
| †Odds ratios, confidence intervals, and p values refer to loss of expression of hMLH1 and hMSH2 compared with ‡individuals with no affected FDR. | ||||||
| ¶Adjusted for age at diagnosis, sex, and family history suggestive of HNPCC (not adjusted for tumour location as all tumours were right sided). | ||||||
| §Adjusted for tumour location, age at diagnosis, sex, and family history suggestive of HNPCC. | ||||||
| FDR with CRC‡ | 0.47 | 0.18–1.25 | 0.13 | 0.16 | 0.01–3.13 | 0.23 |
| No of affected FDR | ||||||
| 0‡ | 1.00 | 1.00 | ||||
| 1 | 0.46 | 0.16–1.29 | 0.14 | – | – | – |
| 2 or 3 | 0.55 | 0.06–5.14 | 0.60 | 0.40 | 0.02–9.79 | 0.57 |
| FDR with extracolonic cancer*‡ | 0.97 | 0.32–2.95 | 0.96 | 2.20 | 0.23–20.96 | 0.49 |
| No of affected FDR | ||||||
| 0‡ | 1.00 | 1.00 | ||||
| 1 | 0.61 | 0.16–2.27 | 0.46 | 2.59 | 0.27–24.89 | 0.41 |
| 2 or 3 | 9.15 | 1.18–70.84 | 0.03 | – | – | – |