Wet weight, sodium, and potassium: faecal excretion, and absolute and relative absorption
| Patient group | Total patients (n) | Patients with beneficial effect | Baseline day –3 to 0 (mean (SD)) | Effect of treatment (treatment−baseline) (mean (SD)) | Effect at follow up (follow up−baseline) (mean (SD)) | |
|---|---|---|---|---|---|---|
| Patients: 16 short bowel syndrome (SBS) patients (11 with jejunostomy and five with colon in continuity) and five rechallenged patients (all with end jejunostomy). | ||||||
| Patients Nos 03 and 15C did not complete the follow up study period. Patient No 03 had only 30% colon and was excluded from group 5 (patients with ⩾50% colon). | ||||||
| R, patients rechallenged with the same dose divided in two injections—that is, 12R is the rechallenged patient No 12. | ||||||
| Effect of treatment: paired t test; treatment versus baseline, *p<0.05, **p<0.01, ***p<0.001. | ||||||
| Effect at follow up: paired t test; follow up versus baseline, all non-significant (p>0.05). | ||||||
| Wet weight | ||||||
| Diet (g/day) | 1. SBS patients | 16 | – | 3339 (1283) | 33 (429) | 74 (341) |
| 2. SBS patients with end jejunostomy | 10 | – | 3276 (1132) | 105 (530) | 60 (403) | |
| 3. SBS patients with ⩾50% colon | 5 | – | 3792 (1534) | −71 (147) | 112 (122) | |
| 4. SBS patients, high dietary compliance | 10 | – | 3581 (1227) | −22 (132) | 69 (126) | |
| 5. Rechallenged (1st treatment) | 5 | – | 3986 (946) | 17 (113) | 37 (132) | |
| 6. Rechallenged (2nd treatment) | 5 | – | 3839 (627) | −283 (584) | −184 (410) | |
| Faecal (g/day) | 1. SBS patients | 16 | 14 | 2770 (1326) | −711 (734)** | 130 (520) |
| 2. SBS patients with end jejunostomy | 10 | 8 | 3258 (1410) | −682 (911)* | 278 (496) | |
| 3. SBS patients with ⩾50% colon | 5 | 5 | 2179 (415) | −822 (341)** | −240 (426) | |
| 4. SBS patients, high dietary compliance | 10 | 9 | 2558 (938) | −769 (447)*** | 93 (500) | |
| 5. Rechallenged (1st treatment) | 5 | 5 | 3549 (1274) | −1063 (349)** | 408 (498) | |
| 6. Rechallenged (2nd treatment) | 5 | 5 | 3333 (1138) | −1450 (837)* | 12 (1353) | |
| Absorption (g/day) | 1. SBS patients | 16 | 15 | 568 (1547) | 743 (477)*** | −55 (605) |
| 2. SBS patients with end jejunostomy | 10 | 9 | 18 (1427) | 788 (551)** | −218 (577) | |
| 3. SBS Patients with ⩾50% Colon | 5 | 5 | 1613 (1503) | 751 (328)** | 352 (525) | |
| 4. SBS patients, high dietary compliance | 10 | 9 | 1023 (1369) | 746 (436)*** | 24 (576) | |
| 5. Rechallenged (1st treatment) | 5 | 5 | 437 (1042) | 1080 (298) ** | −371 (531) | |
| 6. Rechallenged (2nd treatment) | 5 | 5 | 506 (827) | 1167 (456** | −196 (1115) | |
| Absorption (% of intake) | 1. SBS patients | 16 | 14 | 8 (58) | 22 (16)*** | −2 (23) |
| 2. SBS patients with end jejunostomy | 10 | 8 | −7 (64) | 20 (18)** | −9 (16) | |
| 3. SBS patients with ⩾50% colon | 5 | 5 | 31 (39) | 26 (16)* | 17 (30) | |
| 4. SBS patients, high dietary compliance | 10 | 9 | 22 (34) | 23 (16)** | 0 (27) | |
| 5. Rechallenged (1st treatment) | 5 | 5 | 11 (30) | 27 (8)** | −9 (10) | |
| 6. Rechallenged (2nd treatment) | 5 | 5 | 14 (22) | 33 (15)** | −7 (32) | |
| Sodium | ||||||
| Diet (mmol/day) | 1. SBS patients | 16 | – | 159 (65) | 5 (63) | −19 (68) |
| Faecal (mmol/day) | 1. SBS patients | 16 | 12 | 193 (144) | −25 (88) | 30 (129) |
| Absorption (mmol/day) | 1. SBS patients | 16 | 11 | −34 (149) | 30 (95) | −49 (118) |
| Absorption (% of intake) | 1. SBS patients | 16 | 12 | −36 (109) | 38 (70)* | −11 (56) |
| Potassium | ||||||
| Diet (mmol/day) | 1. SBS patients | 16 | – | 61 (36) | 0 (23) | −2 (21) |
| Faecal (mmol/day) | 1. SBS patients | 16 | 12 | 39 (19) | −12 (15)** | −2 (12) |
| Absorption (mmol/day) | 1. SBS patients | 16 | 12 | 22 (36) | 12 (24) | 1 (19) |
| Absorption (% of intake) | 1. SBS patients | 16 | 11 | 7 (80) | 23 (67) | −4 (34) |