Clinical characteristics and methylenetetrahydrofolate reductase (MTHFR) and transcobalamin (TCN) polymorphisms in 72 patients with ulcerative colitis (UC) and 111 controls from central China
| Ulcerative colitis | Controls | p Value | |
|---|---|---|---|
| n | 72 | 118 | |
| Sex (F/M) | 35/37 | 58/60 | 0.9423 |
| Age (y) (mean (SD)) | 41 (15) | 40 (13) | 0.4809 |
| Age of onset (y) (mean (SD)) | 38 (14) | ||
| Current smoker (n (%)) | 1 (1.4) | ||
| Extent of UC (n (%)) | |||
| Rectum | 40 (55.6) | ||
| Left colitis | 15 (20.8) | ||
| Right colon | 1 (1.4) | ||
| Total colon | 17 (23.6) | ||
| Treatment (n (%)) | |||
| 5-ASA/SASP | 53 (73.6) | ||
| Steroids | 15 (20.8) | ||
| Antibiotics | 13 (18.1) | ||
| Intestinal resections (n (%)) | 1 (1.4) | ||
| Genetic polymorphisms (n (%) [95% CI]) | |||
| MTHFR 667T allele | 50 (34.7) [27.3–42.7] | 91 (41.0) [34.7–47.5] | 0.2286 |
| MTHFR 677TT | 10 (13.9) [7.2–23.0] | 21 (18.9) [12.4–26.8] | 0.3707 |
| MTHFR 1298 C allele | 18 (14.1) [8.8–20.7] | 41 (18.5) [13.7–23.9] | 0.2889 |
| MTHFR 677CT+1298AC | 4 (6.2) [2.0–14.0] | 17 (15.3) [9.5–22.7] | 0.0755 |
| MTHFR 677TT/CT+1298AC | 14 (21.2) [12.6–32.0] | 38 (34.2) [25.9–43.3] | 0.0659 |
| TCN 776G allele | 62 (63.3) [53.6–72.3] | 138 (60.0) [53.6–66.2] | 0.5709 |
| TCN 776CG+GG | 42 (85.7) [74.3–93.6] | 89 (77.4) [69.3–84.3] | 0.2236 |
| Total colon | Less extended UC | ||
| MTHFR 677TT+CT/1298AC | 7 (43.7) [22.6–66.6] | 7 (14.0) [6.3–25.2] | 0.0162 |