Clinicopathological features of 92 heterozygous patients with colon cancer stratified by NF1 loss of heterozygosity (LOH) status
| Characteristic | No of cases | NF1 gene LOH | p Value | |
|---|---|---|---|---|
| Negative No (%) | Positive No (%) | |||
| Age (y) | ||||
| Mean age 65.3 (34–95) | ||||
| <70 y | 52 | 40 (76.9) | 12 (23.1) | |
| ⩾70 y | 35 | 28 (80.0) | 7 (20.0) | 0.796 |
| Sex | ||||
| Male | 41 | 31 (75.6) | 10 (24.4) | |
| Female | 51 | 42 (82.3) | 9 (17.7) | 0.449 |
| Tumour size (cm) | ||||
| ⩽5 | 52 | 38 (73.1) | 14 (26.9) | |
| >5 | 7 | 15 (83.3) | 3 (16.7) | 0.529 |
| Histological grade (differentiation) | ||||
| Well | 32 | 25 (78.1) | 7 (21.9) | |
| Moderate | 19 | 14 (73.7) | 5 (26.3) | 0.629 |
| Poor | 12 | 8 (66.7) | 4 (33.3) | |
| Dukes’ stage | ||||
| A | 18 | 12 (66.7) | 6 (33.3) | |
| B | 22 | 20 (90.9) | 2 (9.1) | 0.176 |
| C | 45 | 34 (75.6) | 11 (24.4) | |