Clinical features of the young colorectal cancer patients
| Patient No | Age at colorectal cancer diagnosis (y) | Sex | Site | Presentation | Am I or II | Colorectal polyps | Second cancer, age (y) | |
|---|---|---|---|---|---|---|---|---|
| Gastrointestinal cancer | Non-gastrointestinal cancer | |||||||
| *Patient No 8 is the daughter of patient No15. | ||||||||
| d, deceased. | ||||||||
| Am I, Amsterdam I criteria: three relatives with colorectal cancer (CRC), one of whom is a first degree relative of the other two, CRC involving at least two generations, one or more CRC cases diagnosed before the age of 50 years. | ||||||||
| Am II, Amsterdam II criteria: three relatives with a hereditary non-polyposis colorectal cancer associated tumour (colorectal, endometrial, small bowel, ureter, renal pelvis), one of whom is a first degree relative of the other two, involving at least two generations, one or more cases diagnosed before the age of 50 years. | ||||||||
| 1 | 9 | F | Sigmoid | Vague abdominal pain | 3 polyps (2 adenocarcinoma, 1 adenocarcinoma in situ) | Glioblastoma, 24 | ||
| 2 | 12 (d) | F | Rectum | Rectal bleeding, | 3 adenomatous polyps | |||
| urgency, | ||||||||
| lethargy | ||||||||
| 3 | 13 | M | Sigmoid | Abdominal pain, | ||||
| bowel obstruction | ||||||||
| 4 | 14 | F | Rectosigmoid | Bloody diarrhoea, | ||||
| abdominal pain, | ||||||||
| weight loss | ||||||||
| 5 | 16 (d) | M | Rectosigmoid | Bowel perforation | I | Ovarian, 41 | ||
| 6 | 16 | F | Descending | Abdominal pain, | I | Colorectal, 38 | ||
| obstruction | ||||||||
| 7 | 17 (d) | F | Ascending | Not reported | II | 5 adenomatous polyps | Colorectal, 20 | |
| Colorectal, 32 | ||||||||
| 8* | 18 (d) | F | Caecum | Not reported | I | 3 adenomatous polyps | Rectal, 21 | |
| Duodenal, 28 | ||||||||
| 9 | 20 | M | Sigmoid | Rectal bleeding | I | |||
| 10 | 21 | M | Hepatic flexure | Anaemia | I | |||
| 11 | 22 | M | Splenic flexure | Rectal bleeding, | II | |||
| anaemia | ||||||||
| 12 | 22 (d) | M | Caecum | Anaemia, | I | Endometrial, 46 | ||
| weight loss | ||||||||
| 13 | 22 | F | Rectum | Not reported | Colorectal, 46 | |||
| 14 | 22 | F | Ascending | Not reported | I | Endometrial, 40 | ||
| 15* | 24 (d) | F | Rectum | Abdominal pain, | I | Colorectal, 40 | ||
| constipation and diarrhoea | ||||||||
| 16 | 24 | F | Sigmoid | Not reported | Colorectal, 26 | |||