Negative for dysplasia | Architecture within normal limits. No nuclear abnormalities, except focal nuclear stratification. Greater nuclear alterations acceptable when associated with inflammation, erosion, or ulceration. |
Indefinite | Architecture may be moderately distorted. Nuclear abnormalities less marked than those seen in dysplasia. Changes too marked for negative but not sufficient for the diagnosis of dysplasia. |
Positive for dysplasia | Architectural and cytological changes severe enough to suggest neoplastic transformation. Diagnosis of high grade or low grade based on the severity of changes: high grade dyspasia is diagnosed if either architectural and/or cytological abnormalities are sufficiently prominent. Alterations are especially noteworthy if they involve the mucosal surface. |
Intramucosal carcinoma | Carcinoma has penetrated through the basement membrane of the glands into the lamina propria but not yet invaded the submucosa. |