Dichotomous clinical and biochemical variables significantly influencing mortality in patients with acute liver failure
| Variable | Survivors | Non-survivors | p Value | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Diagnostic accuracy |
|---|---|---|---|---|---|---|
| OR (95% CI), odds ratio (95% confidence interval). | ||||||
| Clinical parameters | ||||||
| Age (y) | ||||||
| <30 | 31 (81.6) | 25 (59.5) | 0.032 | 3.0 (1.1–8.4) | – | – |
| ⩾30 | 7 (18.42) | 17 (40.5) | ||||
| Cerebral oedema | ||||||
| Absent | 33 (86.8) | 19 (45.2) | <0.001 | 8.0 (2.6–24.5) | 12.6 (1.5–108.5) | 70.0 |
| Present | 5 (13.2) | 23 (54.8) | ||||
| Grade 3, 4 encephalopathy | ||||||
| Absent | 16 (42.1) | 6 (14.3) | 0.005 | 4.4 (1.5–12.8) | – | – |
| Present | 22 (57.9) | 36 (85.7) | ||||
| Biochemical parameters | ||||||
| Bilirubin (mg/dl) | ||||||
| <15 | 29 (78.4) | 19 (45.2) | 0.003 | 4.4 (1.6–11.8) | – | – |
| ⩾15 | 8 (21.6) | 23 (54.8) | ||||
| Albumin (mg/dl) | ||||||
| ⩽3 | 17 (54.8) | 30 (81.1) | 0.020 | 3.5 (1.2–10.4) | – | – |
| >3 | 14 (45.2) | 7 (18.9) | ||||
| PT increase (s) | ||||||
| <25 | 23 (67.7) | 11 (26.2) | <0.001 | 5.9 (2.2–15.9) | – | – |
| ⩾25 | 11 (32.3) | 31 (73.8) | ||||
| Bicarbonate (mmol/l) | ||||||
| ⩽20 | 13 (39.4) | 22 (61.1) | 0.071 | 2.4 (0.9–6.4) | – | – |
| >20 | 20 (60.6) | 14 (38.9) | ||||
| pH | ||||||
| ⩽7.40 | 4 (12.50) | 14 (38.9) | 0.014 | 4.5 (1.3–15.5) | 6.6 (0.8–57.5) | 61.8 |
| >7.40 | 28 (87.5) | 22 (61.1) | ||||
| Ammonia (μmol/l) | ||||||
| <124 | 29 (76.3) | 9 (21.4) | <0.001 | 11.8 (4.1–33.8) | 10.9 (5.9–284.0) | 77.5 |
| ⩾124 | 9 (23.7) | 33 (78.6) | ||||