Sex and age adjusted odds ratios (ORs) and 95% confidence intervals (95% CI) of erosive oesophagitis according to the interleukin (IL)-1B, IL-10, and tumour necrosis factor α (TNF-A) genotypes in Helicobacter pylori positive and negative groups
| Polymorphism | H pylori negative | H pylori positive | ||||||
|---|---|---|---|---|---|---|---|---|
| Case/control | OR | p Value | 95% CI | Case/control | OR | p Value | 95% CI | |
| *The number of the case is 0. The frequency of erosive gastritis between TT and CC was compared by Fisher’s exact test (p = 0.02) | ||||||||
| IL-1B C−511T | ||||||||
| C/C | 9/7 | 1 | Referent | 18/44 | 1 | Referent | ||
| C/T | 20/14 | 1.94 | 0.30 | 0.55–6.81 | 42/52 | 1.24 | 0.52 | 0.64–2.40 |
| T/T | 1/6 | 0.35 | 0.39 | 0.03–3.84 | 2/32 | 0.05 | <0.001 | 0.01–0.26 |
| IL-10 T−819C | ||||||||
| T/T | 15/9 | 1 | Referent | 22/53 | 1 | Referent | ||
| C/T | 13/14 | 0.42 | 0.13 | 0.13–1.31 | 30/59 | 0.63 | 0.14 | 0.34–1.17 |
| C/C | 2/4 | –* | –* | – | 10/16 | 0.44 | 0.10 | 0.17–1.16 |
| TNF-A T−1031C | ||||||||
| T/T | 19/13 | 1 | Referent | 45/96 | 1 | Referent | ||
| C/T | 10/12 | 0.78 | 0.70 | 0.22–2.75 | 17/32 | 0.70 | 0.25 | 0.34–1.32 |
| C/C | 1/2 | 0.68 | 0.77 | 0.05–8.90 | 0/0 | – | – | – |