Test | Components of panel | Fibrosis stage | Training or validation | n | AUC | Cut off | SENS | SPEC | PPV | NPV |
---|---|---|---|---|---|---|---|---|---|---|
AST, aspartate aminotransferase; ALT, alanine aminotransferase; HA, hyaluronic acid; TIMP-1, tissue inhibitor of metalloproteinase; PIIINP, aminoterminal peptide of procollagen III; BMI, body mass index; AUC, area under the curve; CI, confidence interval; N/S, not stated; SENS, sensitivity; SPEC, specificity; PPV, positive predictive value; NPV, negative predictive value. | ||||||||||
HA score | Age >45, obesity, AST/ALT ratio >1, diabetes, HA | F3/4 v F0/1/2 | Training | 79 | 0.92 CI (0.85–0.98) | N/S | N/S | N/S | N/S | N/S |
ELF score | Age, HA, TIMP-1, PIIINP | F3/4 v F0/1/2 | Validation | 61 | 0.87 CI (0.66–1) | 0.37 | 89 | 96 | 80 | 98 |
0.46 | 78 | 98 | 87 | 96 | ||||||
BAAT score | Age, BMI, ALT, serum triglycerides | F2/3/4 v F0/1 | Training | 93 | 0.84 CI (N/S) | 0 | 100 | 11 | 33 | 100 |
1 | 100 | 47 | 45 | 100 | ||||||
2 | 71 | 80 | 61 | 86 | ||||||
3 | 14 | 100 | 100 | 73 | ||||||
4 | 0 | 100 | 0 | 70 |