Frequencies of normal and high intestinal permeability with respect to the occurrence of the three CARD15 mutations (3020insC, R702W, and G908R)
| PI | WT | 3020insC | R702W | G908R | 3020insC and R702W | 3020insC and G908R | R702W and G908R | |
|---|---|---|---|---|---|---|---|---|
| WT, wild-type (without CARD15 mutation); 3020insC, R702W, and G908R, mutations of the CARD15 gene (homozygous plus heterozygous); PI, permeability index; CD, Crohn’s disease; CD-R, first degree relative of a patient with CD; CD-NR, non-related household member living with a patient with CD. | ||||||||
| *Significantly different incidence of high and normal permeability between wild-type and mutation subgroups. | ||||||||
| Normal permeability, PI ⩽0.03; high permeability, PI >0.03; χ2 test paired comparison (Fisher’s exact). | ||||||||
| CD | n = 68 | n = 23 | n = 16 | n = 8 | n = 3 | n = 1 | n = 1 | |
| Normal | 38 (56%) | 11 (48%) | 8 (50%) | 5 (63%) | 2 (67%) | 1 (100%) | 1 (100%) | |
| High | 30 (44%) | 12 (52%) | 8 (50%) | 3 (37%) | 1 (33%) | – | – | |
| p = 0.629 | ||||||||
| CD-R | n = 66 | n = 20 | n = 13 | n = 2 | n = 4 | – | – | |
| Normal | 56 (85%) | 12 (60%)* | 10 (77%) | 2 (100%) | 1 (25%) | – | – | |
| High | 10 (15%) | 8 (40%)* | 3 (23%) | – | 3 (75%) | – | – | |
| p = 0.027 | ||||||||
| CD-NR | n = 38 | n = 6 | n = 5 | – | – | – | n = 1 | |
| Normal | 36 (95%) | 6 (100%) | 5 (100%) | – | – | – | 1 (100%) | |
| High | 2 (5%) | – | – | – | – | – | – | |