| Characteristic | NOD2 status—recipient | NOD2 status—donor | ||||
| Wild-type (n = 22) | Mutant (n = 12) | p value | Wild-type (n = 32) | Mutant (n = 3) | p value | |
| Sex | 1.00 | 0.21 | ||||
| Male | 13 | 7 | 23 | 3 | ||
| Female | 9 | 5 | 9 | 0 | ||
| Age | 0.65 | 0.71 | ||||
| <10 years | 12 | 7 | 21 | 3 | ||
| 10–20 years | 1 | 2 | 3 | 0 | ||
| 20–40 years | 3 | 1 | 5 | 0 | ||
| >40 years | 6 | 2 | 3 | 0 | ||
| Race | 0.94 | 0.33 | ||||
| Black | 7 | 5 | 9 | 0 | ||
| White | 13 | 7 | 18 | 3 | ||
| Other | 2 | 0 | 5 | 0 | ||
| Primary pathology | 0.69 | |||||
| Short gut syndrome | 16 | 7 | ||||
| Malrotation | 3 | 2 | ||||
| Gastroschesis | 5 | 2 | ||||
| Necrotising enterocolitis | 2 | 1 | ||||
| Jejunal atresia | 3 | 1 | ||||
| Gardner syndrome | 1 | 1 | ||||
| Hirschsprung | 1 | 0 | ||||
| Prune belly syndrome | 1 | 0 | ||||
| Crohn’s disease | 1 | 2 | ||||
| Motility disorder | 3 | 2 | ||||
| Berdon syndrome | 0 | 2 | ||||
| Idiopathic pseudo-obstruction | 3 | 0 | ||||
| Tumour | 2 | 0 | ||||
| Other | 1 | 1 | 32 | 3 | ||
| Trauma | 1 | 1 | 32 | 3 | ||
| Allograft implanted | Wild-type (n = 23) | Mutant (n = 12) | 0.96 | |||
| Small bowel | 9 | 5 | ||||
| Small bowel and liver | 8 | 4 | ||||
| Multivisceral* | 6 | 3 | ||||
| Individual with any NOD2 mutation | 12/34 | 3/35 | 0.008 | |||
| Excluding individuals with Crohn’s diseas | 10/31 | 3/35 | 0.014 | |||
The term multivisceral is used for a set of organs when pancreas and stomach accompany the small bowel allograft. One wild-type recipient was retransplanted over the course of the study. Of the three mutant donor organs, two were transplanted into mutant recipients and one into a wild-type recipient (see text). p Values were determined as described in the Methods section.