Table 1 Study schedule and procedures

	Enrolment	Investigations	Week	Randomisation	Surgery	pH	Endoscopy	Endoscopy
Visit	1	2	3	4	5	7	8	12
Timing	−3 weeks	−6 weeks	−5 weeks	0	3 months	6 months	1 year	3 years
Endoscopy + biopsy	X		X	X			X	X
24 h pH-metry	X		X			X
Surgery					X
Symptom assessment*	X	X	X	X		X	X	X
Quality of life				X			X
Adverse events*		X	X	X	X	X	X	X

*Also recorded at all intermediate 6 monthly visits after Visit 8.