Effect of vascular endothelial growth factor receptor 2 (VEGFR2) blockade on vascular leakage in cirrhotic rats with ascites
TissueCirrhotic rats (n = 5)Cirrhotic rats + SU11248 (n = 5)
Liver148.2 (20.9)59.7 (5.3)**
Mesentery13.4 (2.2)6.0 (1.0)*
Pancreas10.1 (2.9)17.9 (3.6)
Spleen120.4 (12.4)155.0 (21.2)
Small intestine17.1 (2.9)14.9 (2.5)
Kidney118.3 (27.9)65.3 (23.0)

  • Results (mean (SE)) are given for the regional vascular permeability (μg Evan’s Blue per g tissue).

  • *p<0.01 and **p<0.001 vs control rats.