Table 2

Percentage time when the pH was less than 4

Treatment group	Percentage time pH<4 in 24 h	Percentage time pH<4, diurnal	Percentage time pH<4, nocturnal
Group 1, n = 12
Placebo	14.9	9.5	22.7
ADX10059, 50 mg	15.1	12.8	18.9
Estimate change from baseline	2.71	4.75	0.19
95% Confidence interval	−2.05 to 7.48	0.14 to 9.37	−5.88 to 6.26
p Value	NS	0.0442*	NS

Group 2, n = 11
Placebo	7.2	5.2	9.7
ADX10059, 250 mg	3.6	3.4	3.7
Estimate change from baseline	−6.41	−3.41	−10.37
95% Confidence interval	−11.4 to −1.42	−8.24 to 1.42	−16.73 to −4.01
p Value	0.0144	NS	0.0028

*Increased compared with placebo.
NS, not significant.