Efficacy variable | ADX10059 50 mg tds, (nā=ā12) | Placebo tds, (nā=ā12) | p Value |
Mean (SD) number reflux episodes (pH<4) in 24 h | 65.3 (48.9) | 51.9 (43.3) | NS |
Mean (SD) total duration of reflux episodes (pH<4) in 24 h (min) | 185.3 (136.4) | 184 (172.6) | NS |
Mean (SD) number nocturnal reflux episodes (pH<4) | 28.6 (26.9) | 21.4 (20.7) | NS |
Mean (SD) total duration of reflux episodes (pH<4) nocturnal period (min) | 97.1 (76.6) | 118 (113.3) | NS |
Mean (SD) number of symptomatic episodes | 5.3 (3.3) | 6.6 (4.6) | NS |
Mean (SD) duration of symptomatic episodes (min) | 28.7 (43.9) | 43.2 (81.0) | NS |
NS, not significant; tds, three times daily.