Table 3

Oesophageal tissue infiltration by inflammatory cells

	Visit	Mean	SD	Change from screen (%)	p Value
Mean eosinophils per hpf (ECP⁺ cells)
Mepolizumab (n = 5)	Screening	73.21	50.57
	Week 4	33.83	22.82	−54	0.030
	Week 13	32.72	28.32	−55	0.011
Placebo (n = 6)	Screening	56.71	33.43
	Week 4	53.99	24.51	−5	NS
	Week 13	52.68	28.75	−7	NS
T cells per hpf (CD3⁺ cells)
Mepolizumab (n = 5)	Screening	69.95	19.19
	Week 4	67.86	11.30	−3	NS
	Week 13	67.86	21.94	−3	NS
Placebo (n = 6)	Screening	63.89	18.06
	Week 4	66.99	17.28	+5	NS
	Week 13	66.56	23.65	+4	NS
Mast cells per hpf (tryptase⁺ cells)
Mepolizumab (n = 5)	Screening	25.41	15.18
	Week 4	23.77	11.02	−6	NS
	Week 13	20.57	10.62	−19	NS
Placebo (n = 6)	Screening	23.02	13.19
	Week 4	26.67	12.33	+15	NS
	Week 13	22.59	13.18	−2	NS