| Week | PNR No | PNR mean (SD) | I/IR No | I/IR mean (SD) | All patients No | All patients mean (SD) |
| 4 | 105 | 7.2 (9.2)* | 540 | 9.5 (10.7)* | 645 | 9.1 (10.5)* |
| 8 | 102 | 5.9 (10.8)* | 509 | 9.7 (11.7)* | 611 | 9.1 (11.7)* |
| 12 | 83 | 6.2 (9.8)* | 420 | 10.2 (11.9)* | 503 | 9.5 (11.7)* |
| 24 | 46 | 7.5 (11.4)* | 244 | 12.7 (12.7)* | 290 | 11.9 (12.6)* |
*p<0.001. I/IR, intolerant/initial responders; PNR, primary non-responders; SIBDQ, short inflammatory bowel disease questionnaire.