Modified diagnostic criteria for the diagnosis of autoimmune hepatitis (AIH)103
| Parameter/feature | Score |
| Female sex | +2 |
| ALP:AST (or ALT) ratio | |
| <1.5 | +2 |
| 1.5–3.0 | 0 |
| >3.0 | −2 |
| Serum globulins or IgG above normal | |
| >2.0 | +3 |
| 1.5–2.0 | +2 |
| 1.0–1.5 | +1 |
| <1.0 | 0 |
| ANA, SMA or LKM-1 | |
| >1:80 | +3 |
| 1:80 | +2 |
| 1:40 | +1 |
| <1:40 | 0 |
| AMA positive | −4 |
| Hepatitis viral markers | |
| Positive | −3 |
| Negative | +3 |
| Drug history | |
| Positive | −4 |
| Negative | +1 |
| Average alcohol intake | |
| <25 g/day | +2 |
| >60 g/day | −2 |
| Liver histology | |
| Interface hepatitis | +3 |
| Predominantly lymphoplasmacytic infiltrate | +1 |
| Rosetting of liver cells | +1 |
| None of the above | −5 |
| Biliary changes | −3 |
| Atypical features | −3 |
| Other autoimmune disease(s) | |
| In either patient or first-degree relative | +2 |
| Optional additional parameters | |
| Seropositivity for other defined antibodies | +2 |
| HLA DR3 or DR4 | +1 |
| Response to therapy | |
| Remission alone | +2 |
| Remission with relapse | +3 |
| Interpretation of aggregate scores | |
| Pre-treatment | |
| Definite AIH | >15 |
| Probable AIH | 10–15 |
| Post-treatment | |
| Definite AIH | >17 |
| Probable AIH | 12–17 |
AMA, antimitochondrial antibodies; ANA, antinuclear antibody; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LKM-1, liver kidney microsomal-1 antibody; SMA, smooth muscle antibody.