2007 | 2008 | 2009 | p Value | |
Total population | 255 330 | 255 840 | 255 720 | – |
COX-2 & Newer-NSAID use | 15.0×103 | 14.5×103 | 14.1×103 | <0.001 |
Non-selective NSAID use | 31.7×103 | 32.4×103 | 33.4×103 | <0.001 |
Proton pump inhibitors' use | 75.1×103 | 81.8×103 | 86.6×103 | <0.001 |
NV-UGIB incidence | 134.7 | 125.1 | 89.6 | <0.001 |
C difficile incidence | 122.3 | 104.4 | 72.7 | <0.001 |