Organism | n | Outcome | Reference |
Studies in adult patients | |||
S faecium | 54 | ↓ Global score | Gade et al 216 |
Lactobacillus acidophilus | 18 | ↓ Global score | Halpern et al 217 |
Lactobacillus plantarum 299V | 60 | ↓ Flatulence | Nobaek et al 218 |
L plantarum 299V | 20 | ↓ Pain, ‘all IBS symptoms’ | Niedzielin et al 219 |
L plantarum 299V | 12 | Negative | Sen et al 220 |
L plantarum MF1298 | 16 | Deterioration of symptoms | Ligaarden et al 221 |
L ramnosus GG | 25 | Negative | O'Sullivan et al 240 |
L reuterii ATCC 55730 | 54 | Negative | Niv et al 223 |
L salivarius UCC4331 | 75 | Negative | O'Mahony et al 215 |
Bifidobacterium infantis 35624 | 75 | ↓ Pain and composite score | O'Mahony et al 215 |
B infantis 35624 | 362 | ↓ Pain and composite score | Whorwell et al 224 |
B ifidobacterium lactis DN-173-010 | 274 | ↓ Digestive discomfort | Guyonnet et al 225 |
B lactis DN-173-010 | 34 | ↓ Maximum distension & pain | Agrawal et al 208 |
B ifidobacterium bifidum MIMBb75 | 122 | ↓ Global score | Guglielmetti et al 226 |
Bacillus coagulans GBI-30, 6086 | 52 | ↓ Bowel movements | Dolin222 |
Escherichia coli Nissle 1917 | 120 | ↑ Treatment satisfaction | Kruis et al 227 |
VSL#3® (x8)* | 25 | ↓ Bloating | Kim et al 209 |
VSL#3® (x8)* | 48 | ↓ Flatulence | Kim et al 210 |
Medilac DS® (x2)* | 40 | ↓ Pain | Kim et al 228 |
Mixture (x4)* | 103 | ↓ Global score | Kajander et al 229 |
Mixture (x4)* | 86 | ↓ Global score | Kajander et al 214 |
LAB4 (x4)* | 52 | ↓ Global score | Williams et al 230 |
Mixture (x4)* | 106 | Negative | Drouault-Holowacz et al 231 |
Mixture (x2)* | 40 | ↓ Pain | Sinn et al 232 |
ProSymbioFlor® (x2)* | 297 | ↓ Global score | Enck et al 233 |
Cultura® (x3)* | 74 | Negative | Simrén et al 234 |
Cultura® (x3)* | 52 | Negative | Sondergaard et al 235 |
Mixture (x4)* | 70 | ↓ Pain | Hong et al 236 |
Studies in paediatric patients | |||
L ramnosus GG | 50 | ↓ Abdominal distension | Bausserman and Michail237 |
L ramnosus GG | 104 | ↓ Pain | Gawronska et al 238 |
L ramnosus GG | 141 | ↓ Pain | Francavilla et al 212 |
VSL#3® (x8)* | 59 | ↓ Global score | Guandalini et al 239 |
*Number of organisms in a mixture.
n, number of randomised subjects.
IBS, irritable bowel syndrome; L ramnosus, Lactobacillus ramnosus; L reuterii, Lactobacillus reuterii; L salivarius, Lactobacillus salivarius; S faecium, Streptococcus faecium.