Table 1

Overview of apoptosis-associated transcripts regulated by infliximab (IFX)

Effect of IFXGeneNameFunctionReference
Downregulation CIAPIN1 Cytokine-induced apoptosis inhibitor 1Anti-apoptotic 19
API5 Apoptosis inhibitor 5Anti-apoptotic 20
Upregulation PDCD4 Programmed cell death 4Anti-proliferative, pro-apoptotic 21
PDCD6 Programmed cell death 6Ca2+ binding, pro-apoptotic 23
BTG1 B-cell translocation gene 1Pro-apoptotic, anti-proliferative 24
BIRC4BP XIAP associated factor 1Pro-apoptotic, antagonist of XIAP 22
BNIP3L BCL2/adenovirus E1B 19 kDa interacting protein 3-likePro-apoptotic, target of p53 25
  • BCL2, B-cell lymphoma 2; XIAP, X-linked inhibitor of apoptosis.