Performance of KRAS, BRAF and PIK3CA mutation signatures in training and validation set
| KRAS signature | BRAF signature | PI3K signature | |
| Training set (n=381) | |||
| Sensitivity (%) | 91 | 90 | 75 |
| Specificity (%) | 62 | 92 | 80 |
| Accuracy (%) | 72 | 91 | 79 |
| Area under the ROC curve* | 0.846 | 0.948 | 0.853 |
| 95% CI | (0.801 to 0.883) | (0.912 to 0.972) | (0.803 to 0.894) |
| z statistic | 16.338 | 23.254 | 11.868 |
| Significance level P (area=0.5) | <0.0001 | <0.0001 | <0.0001 |
| Validation set (n=80) | |||
| Sensitivity (%) | 93 | 100 | 69 |
| Specificity (%) | 65 | 93 | 78 |
| Accuracy (%) | 77 | 93 | 75 |
| Area under the ROC curve (AUC) | 0.872 | 0.981 | 0.812 |
| 95% CI | (0.770 to 0.941) | (0.886 to 1.000) | (0.686 to 0.904) |
| z statistic | 8.579 | 24.350 | 4.818 |
| Significance level P (area=0.5) | <0.0001 | <0.0001 | <0.0001 |
↵* Calculated from training samples used for each signature (AUC).