Predictive values of the IL28B genetic variants in HCV genotype 1 and HCV genotype 3-infected individuals receiving standard therapy.
| Viral Genotype | Host marker | Reference variant | Risk variant | Specificity% | Sensitivity% | PPV% | NPV% |
|---|---|---|---|---|---|---|---|
| Gen 1 | rs12979860 | C* | TT | 93.5 | 30.2 | 81.3 | 58.9 |
| CC | T* | 52.2 | 83.7 | 62.1 | 77.4 | ||
| rs4803221 | C* | GG | 95.7 | 14.0 | 75.0 | 54.3 | |
| CC | G* | 63.0 | 69.8 | 63.8 | 69.0 | ||
| rs8099917 | T* | GG | 95.7 | 14.0 | 75.0 | 54.3 | |
| TT | G* | 63.0 | 67.4 | 63.0 | 67.4 | ||
| rs7248668 | G* | AA | 95.7 | 14.0 | 75.0 | 54.3 | |
| GG | A* | 60.9 | 65.1 | 60.9 | 65.1 | ||
| Gen 3 | rs12979860 | C* | TT | 91.2 | 4.0 | 16.7 | 68.4 |
| CC | T* | 47.4 | 52.0 | 30.2 | 69.2 | ||
| rs4803221 | C* | GG | 98.2 | 0.0 | 0.0 | 69.1 | |
| CC | G* | 61.4 | 44.0 | 33.3 | 71.4 | ||
| rs8099917 | T* | GG | 98.2 | 0.0 | 0.0 | 69.1 | |
| TT | G* | 61.4 | 44.0 | 33.3 | 71.4 | ||
| rs7248668 | G* | AA | 98.2 | 4.0 | 50.0 | 70.0 | |
| GG | A* | 63.2 | 44.0 | 34.4 | 72.0 |