Evidence based (published) sorafenib target genes
| Symbol | Gene name | Location | Function |
|---|---|---|---|
| AIFM1 | Apoptosis-inducing factor, mitochondrion-associated, 1 | Cytoplasm | Apoptosis |
| Akt1 | V-akt murine thymoma viral oncogene homologue | Cytoplasm | Proliferation, survival |
| ALDH1A1 | Aldehyde dehydrogenase 1 family, member A1 | Cytoplasm | Alcohol metabolism, cancer stem cells marker |
| ATG5 | ATG5 autophagy-related 5 homologue | Cytoplasm | Autophagy, apoptosis |
| BAD | BCL2-associated agonist of cell death | Cytoplasm | Apoptosis |
| BAK1 | BCL2-antagonist/killer 1 | Cytoplasm | Apoptosis |
| BAX | BCL2-associated X protein | Cytoplasm | Apoptosis |
| BCL2L1 | BCL2-like 1 | Cytoplasm | Survival |
| BID | BH3 interacting domain death agonist | Cytoplasm | Apoptosis |
| BRAF | V-raf murine sarcoma viral oncogene homologue b1 | Cytoplasm | Proliferation |
| CASP3, 7, 8, 9 | Caspase 3, 7, 8, 9 apoptosis-related cysteine peptidase | Cytoplasm | Apoptosis |
| CCND 1, 3 | Cyclin D1, 3 | Nucleus | Cell cycle |
| CDK 4, 6 | Cyclin-dependent kinase 4, 6 | Nucleus | Cell cycle |
| CFLAR | CASP8 and FADD-like apoptosis regulator | Cytoplasm | Survival |
| CRKL | V-crk sarcoma virus CT10 oncogene homologue | Cytoplasm | Proliferation |
| CYP2B6, C19, C8, D6 | Cytochrome P450, family 2 | Cytoplasm | Drug metabolism, lipid synthesis |
| CYP3A4 | Cytochrome P450, family 3, subfamily A, polypeptide 4 | Cytoplasm | Drug metabolism, lipid synthesis |
| DDIT3 | DNA-damage-inducible transcript 3 | Nucleus | Adipogenesis, erythropoiesis, apoptosis |
| DIABLO | Diablo, IAP-binding mitochondrial protein | Cytoplasm | Survival |
| DOK1 | Docking protein 1, 62 kDa (downstream of tyrosine kinase 1) | Membrane | Proliferation, survival |
| EIF2A, 2AK3, 2S1, 4E, 4EBP1 | Eukaryotic translation initiation factor, 65 kda | Cytoplasm | Protein translation, survival |
| ERN1 | Endoplasmic reticulum to nucleus signalling 1 | Cytoplasm | Apoptosis, stress response |
| FAS | Fas (tumor necrosis factor receptor superfamily, member 6) | Membrane | Apoptosis |
| FLT 3, 4 | Fms-related tyrosine kinase 3, 4 | Membrane | Proliferation, survival |
| HIF1A | Hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor) | Nucleus | Apoptosis, hypoxia response |
| HSPA5 | Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) | Cytoplasm | Stress response |
| KDR | Kinase insert domain receptor (a type III receptor tyrosine kinase) | Membrane | Proliferation, survival |
| KIT | V-kit Hardy–Zuckerman 4 feline sarcoma viral oncogene homologue | Membrane | Proliferation, survival |
| MAPK1, 3 | Mitogen-activated protein kinase 1, 3 | Cytoplasm | Proliferation |
| MCL1 | Myeloid cell leukaemia sequence 1 (BCL2-related) | Cytoplasm | Survival/apoptosis |
| PDGFRB | Platelet derived growth factor receptor, β polypeptide | Membrane | Proliferation, survival |
| PPP1R15A | Protein phosphatase 1, regulatory (inhibitor) subunit 15A | Cytoplasm | Apoptosis, DNA damage response |
| Ptk2 | Protein tyrosine kinase | Cytoplasm | Proliferation |
| RAF1 | V-raf-1 murine leukaemia viral oncogene homologue 1 | Cytoplasm | Proliferation |
| RELA | V-rel reticuloendotheliosis viral oncogene homologue A | Nucleus | Proliferation, survival |
| RPS6KB1 | Ribosomal protein s6 kinase, 70 kda, polypeptide 1 | Cytoplasm | Proliferation, protein synthesis |
| SNRPE | Small nuclear ribonucleoprotein polypeptide E | Nucleus | Transcription, RNA processing |
| STAT5a/b | Signal transducer and activator of transcription 5B | Cytoplasm | Proliferation, survival |
| TWIST2 | Twist homologue 2 (drosophila) | Nucleus | Epithelia–mysenchymal transition |
| VIM | Vimentin | Cytoplasm | Epithelia–mysenchymal transition |