Univariate and multivariate Cox regression analysis for stromal super-module expression and clinicopathological characteristics in the combined validation series
| Covariate | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95.0% CI) | p Value | HR (95.0% CI) | p Value | |
| Stromal module expression | ||||
| Continuous variable | 1.007 (1.001 to 1.013) | 0.025 | 1.005 (0.999 to 1.012) | 0.12 |
| Age | ||||
| <65 years | 1 | 1 | ||
| ≥65 years | 1.501 (1.072 to 2.103) | 0.018 | 1.690 (1.169 to 2.442) | 0.005 |
| Gender | ||||
| Female | 1 | 1 | ||
| Male | 1.488 (1.035 to 2.141) | 0.032 | 1.287 (0.858 to 1.931) | 0.223 |
| Morphology | ||||
| Intestinal | 1 | – | – | |
| Diffuse | 1.167 (0.819 to 1.661) | 0.392 | – | – |
| Unclassifiable | 1.002 (0.584 to 1.718) | 0.995 | – | – |
| Resection margin status | ||||
| R0 | 1 | – | – | |
| R | 1.511 (0.89 to 2.564) | 0.126 | – | – |
| Grade of differentiation | ||||
| G1 | 1 | 1 | ||
| G2 | 4.242 (1.525 to 11.801) | 0.006 | 2.926 (1.029 to 8.320) | 0.044 |
| G3 | 4.735 (1.731 to 12.949) | 0.002 | 3.429 (1.229 to 9.569) | 0.019 |
| AJCC staging | ||||
| Stage I | 1 | 1 | ||
| Stage II | 2.346 (1.045 to 5.264) | 0.039 | 1.924 (0.853 to 4.341) | 0.115 |
| Stage III | 4.649 (2.308 to 9.366) | <0.001 | 4.126 (2.023 to 8.415) | <0.001 |
| Stage IV | 12.002 (5.801 to 24.833) | <0.001 | 10.786 (5.035 to 23.106) | <0.001 |