Comparative studies between standard and advanced imaging techniques for the diagnosis of IM and dysplasia in Barrett's oesophagus
| Study | Year | Technique | Study design | No of patients | Increased detection of IM | Increased detection of dysplasia | Grade of evidence |
|---|---|---|---|---|---|---|---|
| Sharma et al145 | 2001 | MB | Cohort | 158 | p=0.024 | N/A | IIb |
| Canto et al147 | 2000 | MB | Randomised MB vs WLE | 43 | p=0.0001 | p=0.03 | Ib |
| Ragunath et al150 | 2003 | MB | Randomised cross-over | 57 | p=0.032 | p=ns | Ib |
| Wo et al151 | 2001 | MB | Randomised cross-over | 47 | p=ns | p=ns | Ib |
| Horwhat et al149 | 2008 | MB | Randomised cross-over | 48 | p=ns | p=ns | Ib |
| Gossner et al146 | 2006 | MB | Cohort cross-over | 86 | N/A | p=0.053 | IIa |
| Lim et al148 | 2006 | MB | Randomised cross-over | 30 | N/A | p=0.02* | Ib |
| Ngamruengphong et al152 | 2009 | MB | Meta-analysis | 450 | p=ns | p=ns | Ia |
| Kara et al139 | 2005 | IC/NBI | Randomised cross-over | 28 | N/A | p=ns | Ib |
| Hoffman et al156 | 2006 | AA | Randomised cross-over | 31 | p<0.001 | N/A | Ib |
| Ferguson et al157 | 2006 | AA | Randomised | 137 | p=ns | N/A | Ib |
| Longcroft-Wheaton et al160 | 2010 | AA | Retrospective cohort | 190 | N/A | p=0.001 | III |
| Wolfsen et al165 | 2008 | NBI | Cohort tandem | 65 | N/A | p<0.001 | IIa |
| Sharma et al166 | 2013 | NBI | Randomised cross-over | 123 | N/A | p=ns | Ib |
| Curvers et al174 | 2010 | ETMI | Randomised cross-over | 87 | N/A | p=ns | Ib |
| Curvers et al175 | 2011 | ETMI | Randomised cross-over | 99 | N/A | p=ns | Ib |
*Higher yield of dysplasia in WLE with random biopsies compared with MB chromoendoscopy.
AA, acetic acid; ETMI, endoscopic trimodal imaging; IC, indigo carmine; IM, intestinal metaplasia; MB, methylene blue; NBI, narrow band imaging; WLE, white light endoscopy.