Table 10

Summary of clinical profiles of different ablative techniques for HGD

TechniqueRate of dysplasia eradicationAdvantagesDisadvantages
Step-wise radical ER97–100%

  • Accurate diagnosis

  • Low costs

  • High risk of stenosis

  • Feasible only for Barrett's oesophagus <5 cm

APC67–86%

  • Large availability

  • Low costs

  • Buried glands

  • Feasible for short segments only

PDT40–77%

  • RCT available

  • Treatment of nodular dysplasia

  • High risk of stricture

  • Buried glands

  • Photosensitivity

RFA 80–98%

  • RCT available

  • High response rate

  • Low complication rate

  • High costs

  • No long-term follow-up data

Cryotherapy68–88%

  • Good safety profile

  • Small studies (no RCTs)

  • No long-term follow-up data

  • APC, argon plasma coagulation; ER,endoscopic resection; PDT, photodynamic therapy; RCT, randomised controlled trial; RFA, radiofrequency ablation.