Tissue biodistribution of (3H)VA-lip-siRNAgp46 in rats
| Radioactivity (cpm/tissue) | ||||
|---|---|---|---|---|
| Normal (×105) | DBTC rat (×105) | p Value (normal vs DBTC rat) | Ratio (DBTC rat/ normal) | |
| Pancreas | 0.481±0.270 | 2.42±0.840 | 0.001 | 5.03 |
| Liver | 77.2±21.0 | 319±105 | 0.002 | 4.14 |
| Lung | 3.83±1.89 | 5.26±3.66 | NS | 1.37 |
| Spleen | 1.75±0.740 | 1.84±1.11 | NS | 1.05 |
| Intestine | 4.23±1.59 | 4.52±1.00 | NS | 1.07 |
DBTC-treated rats (day 43 rat) and normal rats (n=3 per group) received a single intravenous injection of 200 μCi (3H)VA-lip-siRNAgp46 via the tail vein. Tissue biodistribution was analysed 24 h later. Data represent means±SD (n=3). Similar results were obtained in two independent experiments.
DBTC, dibutyltin dichloride; NS, not significant; VA-lip-siRNAgp46, vitamin A-coupled liposomes.