Diagnostic accuracy of endoscopic diagnosis with NBI to distinguish between neoplastic and non-neoplastic colorectal neoplasms
| Summary estimates (95% CI) | Likelihood ratio (95% CI) | |||||
|---|---|---|---|---|---|---|
| Study characteristics | No. of studies (no. of polyps) | Sens | Spec | LR+ | LR− | Area under HSROC curve (95% CI) |
| All | 28 (6280) | 91.0 (87.6 to 93.5) | 82.6 (79.0 to 85.7) | 5.2 (4.3 to 6.4) | 0.11 (0.08 to 0.15) | 0.92 (0.90 to 0.94) |
| Published manuscripts | 18 (3212) | 91.7 (87.1 to 97.4) | 84.5 (80.4 to 87.9) | 5.9 (4.6 to 7.6) | 0.10 (0.06–0.16) | 0.93 (0.90–0.95) |
| High-confidence predictions20–22 31 38–41 | 8 (2146) | 93.8 (90.1 to 96.2) | 83.3 (77.1 to 88.1) | 5.6 (4.0 to 7.8) | 0.07 (0.05 to 0.12) | 0.95 (0.93 to 0.97) |
| Polyps ≤5 mm19 21 22 30 38 39 | 7 (1942) | 86.3 (78.4 to 91.7) | 84.1 (75.5 to 90.1) | 5.4 (3.6 to 8.2) | 0.16 (0.11 to 0.25) | 0.92 (0.89 to 0.94) |
| High-confidence predictions for polyps ≤5 mm21 22 38–40 | 5 (1350) | 93.4 (87.4 to 96.7) | 84.0 (76.6 to 89.3) | 5.8 (4.0 to 8.6) | 0.08 (0.04 to 0.15) | 0.94 (0.92 to 0.96) |
| Exera | 20 (5148) | 89.4 (85.0 to 92.6) | 81.6 (77.3 to 85.2) | 4.9 (3.9 to 6.0) | 0.13 (0.09 to 0.18) | 0.91 (0.89 to 0.94) |
| Lucera | 8 (1132) | 94.0 (88.7 to 96.9) | 86.0 (81.1 to 89.8) | 6.7 (4.9 to 9.2) | 0.07 (0.04 to 0.13) | 0.95 (0.93 to 0.97) |
| Highest-quality studies17 29 32 38 39 | 5 (826) | 91.5 (86.0 to 94.8) | 87.2 (74.7 to 94.1) | 7.2 (3.4 to 15.0) | 0.10 (0.06 to 0.16) | 0.95 (0.93 to 0.97) |
| High-quality studies17 21 24 26 29 31–33 38 39 41 43 | 12 (2428) | 88.3 (83.6 to 91.8) | 85.3 (80.3 to 89.2) | 6.0 (4.3 to 8.4) | 0.14 (0.09 to 0.20) | 0.93 (0.91 to 0.95) |
HSROC, hierarchical summary receiver-operating characteristic; NBI, narrow band imaging.