Table 1

The different datasets included in this study: a discovery set for single SNP OR calculation, a derivation set to create the risk models, two validation sets to validate the risk model, and a test set to evaluate the model in clinical practice

Cohorts	Discovery set: case–control		Derivation set: case–control		Validation set 1: nested case–control		Validation set 2: prospective		Test set: case–control
Cohorts	Cases	Controls	Cases	Controls	Cases	Controls	CDA	No CDA	Cases	Controls
Italy	695	635	693	635					99	219
The Netherlands	535	586	535	583					61	175
Poland	235	270	236	269					50	67
Spain 1	242	171	242	170					34	122
Spain 2	268	160	269	159					33	125
UK	700	1000	700	999
Sweden					306	1403
Non-Hispanic white American							70	1174
Sub-total	2675	2822	2675	2815	306	1403	70	1174	277	708
Total	5497		5490		1709		1244		985

CDA, coeliac disease autoimmunity; SNP, single-nucleotide polymorphism.