Effect of PAKs on cell signalling cascades in GI disease
| Effect of PAKs on signalling cascades | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease | Wnt/β-catenin | MAPK | PI3K | mTOR | NF-κB | Reference | |||||
| PAK1 | PAK4 | PAK1 | PAK4 | PAK1 | PAK4 | PAK1 | PAK4 | PAK1 | PAK4 | ||
| IBD | − | − | − | − | − | − | − | − | + | − | 76 88 105 |
| Colorectal cancer | + | − | + | + | + | + | + | − | − | − | 13 14 59 74 76 91 92 152 |
| Gastric cancer | + | − | + | + | − | + | − | − | + | − | 16 130 137 166 |
| Oesophageal squamous cell carcinoma | − | − | + | − | − | − | − | − | − | − | 145 |
| Hepatocellular carcinoma | − | − | + | − | − | + | − | − | − | − | 18 44 |
(+) investigated; (−) not investigated.
MAPK, mitogen activated protein kinase; PAK, P-21 activated kinase; PI3K, phospoinositide 3-kinase.