Subject demographics
| Patient group | N | Gender M/F | Age years Mean (SEM) | Bowel movements/day Median (IQR) | Anxiety HADS Mean (SEM) | |
|---|---|---|---|---|---|---|
| Part 1 | Healthy volunteers | 9 | 3/6 | 25.4 (2.3) | 1.4 (0.7–2.0) | ND |
| IBS-D | 36 | 11/25 | 39 (2) | 2.8 (2.1–4.2) | 9.0 (0.8) | |
| Part 2a | Healthy volunteers | 21 | 5/16 | 42.8 (4) | 1.1 (1–1.4) | 5.2 (0.6) |
| IBS-D | 79 | 22/57 | 41 (2) | 2.7 (2–3.9) | 9.2 (0.6) | |
| Part 2b | Healthy volunteers | 24 | 12/12 | 26.5 (3) | 1.3 (1.1–1.5) | 3.5 (0.7) |
HADS, Hospital Anxiety and Depression Score; IBS-D, irritable bowel syndrome with diarrhoea; ND, not done.