Proportion of patients receiving besifovir 90 or 150 mg daily with carnitine (normal 34–78 µmol/L) and phosphorus drug toxicity
| Phosphorus | Besifovir 90 mg | Besifovir 150 mg | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Week of follow-up | I (%) | II (%) | III (%) | IV (%) | Week of follow-up | I (%) | II (%) | III (%) | IV (%) |
| 2 (n=34) | 1 (2.94) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 2 (n=39) | 2 (5.13) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 4 (n=36) | 1 (2.78) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 4 (n=38) | 1 (2.63) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 8 (n=36) | 2 (5.56) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 8 (n=38) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 12 (n=36) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 12 (n=38) | 2 (5.26) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 16 (n=36) | 0 (0.00) | 1 (2.78) | 0 (0.00) | 0 (0.00) | 16 (n=38) | 2 (5.26) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 20 (n=35) | 2 (5.71) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 20 (n=37) | 1 (2.70) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 24 (n=35) | 2 (5.71) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 24 (n=38) | 1 (2.63) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 32 (n=34) | 3 (8.82) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 32 (n=38) | 1 (2.63) | 1 (2.63) | 0 (0.00) | 0 (0.00) |
| 40 (n=34) | 1 (2.94) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 40 (n=38) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| 48 (n=34) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 48 (n=38) | 2 (5.26) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| Carnitine | Besifovir 90 mg | Besifovir 150 mg | |||||
|---|---|---|---|---|---|---|---|
| Week of follow-up | Low | Normal | High | Week of follow-up | Low | Normal | High |
| 2 (n=35) | 6 (17.14) | 29 (82.86) | 0 (0.00) | 2 (n=39) | 14 (35.90) | 25 (64.10) | 0 (0.00) |
| 4 (n=36) | 10 (27.78) | 26 (72.22) | 0 (0.00) | 4 (n=38) | 20 (52.63) | 18 (47.37) | 0 (0.00) |
| 8 (n=36) | 10 (27.78) | 26 (72.22) | 0 (0.00) | 8 (n=38) | 17 (44.74) | 20 (52.63) | 1 (2.63) |
| 12 (n=36) | 3 (8.33) | 32 (88.89) | 1 (2.78) | 12 (n=38) | 6 (15.79) | 30 (78.95) | 2 (5.26) |
| 16 (n=36) | 3 (8.33) | 31 (94.44) | 2 (5.56) | 16 (n=38) | 6 (15.79) | 31 (81.58) | 1 (2.63) |
| 20 (n=35) | 7 (20.00) | 28 (80.00) | 0 (0.00) | 20 (n=37) | 11 (29.73) | 26 (70.27) | 0 (0.00) |
| 24 (n=35) | 2 (5.71) | 33 (94.29) | 0 (0.00) | 24 (n=38) | 11 (28.95) | 26 (68.42) | 1 (2.63) |
| 32 (n=34) | 2 (5.88) | 32 (94.12) | 0 (0.00) | 32 (n=38) | 12 (31.58) | 25 (65.79) | 1 (2.63) |
| 40 (n=34) | 3 (8.82) | 31 (91.18) | 0 (0.00) | 40 (n=38) | 7 (18.42) | 31 (81.58) | 0 (0.00) |
| 48 (n=34) | 8 (23.53) | 26 (76.47) | 0 (0.00) | 48 (n=38) | 3 (7.89) | 33 (86.84) | 2 (5.26) |