Univariable and multivariable Cox regression analysis of the lncRNA signature and survival in the training set (n=60) and in the combined test and independent cohort (n=119)
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | ||
| Training set | |||||
| Age | >60/≤60 | 1.595 (0.821 to 3.098) | 0.1680 | 2.366 (1.191 to 4.701) | 0.0140 |
| Gender | Female/male | 1.233 (0.561 to 2.707) | 0.6022 | ||
| Tobacco use | Y/N | 0.693 (0.357 to 1.346) | 0.2790 | ||
| Alcohol use | Y/N | 0.896 (0.464 to 1.732) | 0.7445 | ||
| Tumour location | Upper, middle/lower | 1.249 (0.602 to 2.591) | 0.5504 | ||
| Tumour grade | Moderately differentiated, poorly/well differentiated | 1.569 (0.685 to 3.592) | 0.2863 | ||
| T | T3, T4/T1, T2 | 0.767 (0.319 to 1.845) | 0.5540 | ||
| N | N1, N2, N3/N0 | 1.960 (0.974 to 3.943) | 0.0592 | ||
| TNM | III/I, II | 2.506 (1.202 to 5.226) | 0.0143 | ||
| Pneumonia | Y/N | 1.050 (0.144 to 7.672) | 0.9614 | ||
| Anastomotic leak | Y/N | 2.716 (0.829 to 8.892) | 0.0987 | 5.805 (1.605 to 21.000) | 0.0073 |
| Arrhythmia | Y/N | 1.416 (0.706 to 2.837) | 0.3271 | ||
| Adjuvant therapy | Y/N | 1.501 (0.849 to 2.652) | 0.1625 | ||
| LncRNA signature | High risk/low risk | 6.578 (2.837 to 15.252) | <0.0001 | 8.486 (3.550 to 20.284) | <0.0001 |
| Test+independent cohort | |||||
| Age | >60/≤60 | 1.724 (1.072 to 2.774) | 0.0246 | 1.674 (1.033 to 2.713) | 0.0365 |
| Gender | Female/male | 1.283 (0.714 to 2.306) | 0.4045 | ||
| Tobacco use | Y/N | 0.788 (0.488 to 1.272) | 0.3295 | ||
| Alcohol use | Y/N | 0.866 (0.539 to 1.390) | 0.5501 | ||
| Tumour location | Upper, middle/lower | 1.184 (0.719 to 1.951) | 0.5065 | ||
| Tumour grade | moderately differentiated, poorly/well differentiated | 0.982 (0.502 to 1.919) | 0.9571 | ||
| T | T3, T4/T1, T2 | 1.237 (0.716 to 2.183) | 0.4458 | ||
| N | N1, N2, N3/N0 | 2.214 (1.346 to 3.640) | 0.0017 | ||
| TNM | III/I, II | 2.031 (1.258 to 3.278) | 0.0037 | ||
| Pneumonia | Y/N | 1.507 (0.721 to 3.152) | 0.2759 | ||
| Anastomotic leak | Y/N | 0.942 (0.343 to 2.589) | 0.9085 | ||
| Arrhythmia | Y/N | 0.976 (0.558 to 1.705) | 0.9311 | ||
| Adjuvant therapy | Y/N | 2.227 (1.241 to 3.997) | 0.0073 | 2.328 (1.299 to 4.172) | 0.0045 |
| LncRNA signature | High risk/low risk | 2.412 (1.464 to 3.975) | 0.0005 | 2.203 (1.330 to 3.649) | 0.0022 |
TNM, tumour node metastasis.