Table 2

Driver genes for cancer in transformed clones

Gene symbol	Classification2	Fold-change in gene expression in transformed clones*
Gene symbol	Classification2	H2	H3	H5	H7	M3	37M10-3	M11	M13	M15	M17
Arid1b	TSG†	−1.93	−2.04	−1.67	−2.09	−1.89	−1.73	−1.53	−1.80	−1.32	−1.23
Cdkn2a	TSG	−1.01	−1.20	−1.58	−1.01	−3.13	−2.47	−3.51	−2.94	−3.44	−3.57
Daxx	TSG	1.46	1.65	−1.05	1.69	2.43	1.28	1.43	2.25	1.60	1.44
Gata3	TSG	1.10	−.03	−1.68	1.08	1.70	2.52	2.39	1.68	1.65	2.29
Map3k1	TSG	−1.87	−1.42	−1.20	−1.83	−2.42	−3.07	−2.02	−2.64	−1.93	−2.61
Notch1	TSG	2.49	1.69	−1.06	1.35	2.49	3.34	−1.07	3.77	1.23	1.26
Pbrm1	TSG	−1.94	−1.68	−1.33	−2.04	−1.92	−1.58	−1.70	−1.47	1.00	−1.01
Pten	TSG	2.20	1.92	1.80	1.49	1.27	−1.03	1.49	1.53	1.09	1.20
Smad2	TSG	1.01	−1.31	1.08	1.09	−2.21	−2.08	−1.47	−1.86	−1.79	−1.89
Traf7	TSG	−2.08	−1.83	−2.27	−1.59	−1.17	1.12	−1.13	1.10	1.25	−1.09
Egfr	Oncogene	1.25	1.19	−1.31	1.26	−1.66	−2.08	−2.22	−1.56	−3.59	−2.27
Gata2	Oncogene	−1.60	−1.14	−2.01	−1.36	−1.28	1.15	−1.05	1.01	1.21	1.00
Klf4	Oncogene	2.07	2.43	1.70	1.99	2.37	2.31	1.90	1.52	1.86	2.39
Pdgfra	Oncogene	−3.95	−4.18	−3.95	−4.21	−1.37	−1.56	−2.20	−1.59	−2.11	−2.23
Ppp2r1a	Oncogene	−1.76	−1.77	−1.56	−2.04	−1.27	−1.23	−1.38	−1.11	1.00	−1.12
Number of driver genes with ≥ 2.00 fold-change		5	3	3	4	6	7	5	4	3	6