Univariate HRs (95% CI) of known and potential risk factors for metachronous gastric cancer
| Authentic metachronous gastric cancers | All metachronous gastric cancers | |||||
|---|---|---|---|---|---|---|
| Variable | No. of events | HR | p Value | No. of events | HR | p Value |
| Hospital | ||||||
| NCC | 52 | 1 | 59 | 1 | ||
| TYU | 6 | 1.03 (0.44 to 2.40) | 0.95 | 10 | 1.43 (0.73 to 2.80) | 0.30 |
| WMU | 8 | 1.77 (0.84 to 3.73) | 0.14 | 12 | 2.26 (1.21 to 4.21) | 0.01 |
| Age | ||||||
| ≥70 | 27 | 1 | 34 | 1 | ||
| <50 | 4 | 3.50 (1.23 to 10.0) | 0.019 | 4 | 2.76 (0.98 to 7.79) | 0.055 |
| 50–59 | 6 | 0.58 (0.24 to 1.39) | 0.22 | 9 | 0.71 (0.34 to 1.48) | 0.36 |
| 60–69 | 29 | 0.91 (0.54 to 1.54) | 0.72 | 34 | 0.86 (0.54 to 1.39) | 0.55 |
| Gender | ||||||
| Male | 60 | 1 | 74 | 1 | ||
| Female | 6 | 0.43 (0.19 to 1.00) | 0.049 | 7 | 0.41 (0.19 to 0.89) | 0.023 |
| Pepsinogen index | ||||||
| (−) | 28 | 1 | 35 | 1 | ||
| (+) | 5 | 2.18 (0.83 to 5.68) | 0.11 | 6 | 1.88 (0.79 to 4.50) | 0.15 |
| (2+) | 16 | 1.65 (0.89 to 3.06) | 0.11 | 18 | 1.44 (0.82 to 2.55) | 0.21 |
| (3+) | 17 | 1.56 (0.85 to 2.87) | 0.15 | 22 | 1.54 (0.90 to 2.63) | 0.12 |
| H. pylori infection before the enrolment | ||||||
| Positive | 41 | 1 | 31 | 1 | ||
| Negative | 25 | 1.02 (0.61 to 1.71) | 0.94 | 50 | 0.93 (0.58 to 1.47) | 0.74 |
| Past history of ER (times) | ||||||
| 0 | 13 | 1 | 16 | 1 | ||
| 1 | 43 | 1.18 (0.63 to 2.19) | 0.6 | 49 | 1.10 (0.63 to 1.93) | 0.74 |
| 2 | 5 | 0.81 (0.29 to 2.29) | 0.69 | 10 | 1.38 (0.62 to 3.04) | 0.43 |
| 3 | 5 | 5.66 (2.01 to 15.9) | 0.001 | 6 | 5.46 (2.13 to 14.0) | 0.0004 |
| Smoking (pack-years) | ||||||
| 0 | 15 | 1 | 18 | 1 | ||
| 1–39 | 17 | 1.17 (0.57 to 2.40) | 0.66 | 25 | 1.55 (0.85 to 2.83) | 0.15 |
| ≥40 | 29 | 2.24 (1.27 to 3.96) | 0.006 | 32 | 2.06 (1.21 to 3.50) | 0.007 |
| Green vegetable intake (per week) | ||||||
| ≤2 days | 20 | 1 | 25 | 1 | ||
| 3–4 days | 25 | 0.67 (0.37 to 1.21) | 0.18 | 32 | 0.69 (0.41 to 1.16) | 0.16 |
| Almost daily | 18 | 0.65 (0.34 to 1.23) | 0.18 | 20 | 0.57 (0.32 to 1.02) | 0.06 |
p values <0.05 are shown in bold type.
ER, endoscopic resection; NCC, National Cancer Center Hospital; TYU, Tokyo University Hospital; WMU, Wakayama Medical University Hospital.