HLA Class I and II associations with viral outcome in patients from the Irish stratified by their IFNL3 rs12979860 genotype (Fishers exact test)
| IFNL3 rs12979860 CC genotype | IFNL3 rs12979860 T+ genotype | |||||||
|---|---|---|---|---|---|---|---|---|
| HLA | Chronic n=62 (%) | Resolved n=94 (%) | OR (95% CI) | p Value | Chronic n=134 (%) | Resolved n=29 (%) | OR (95% CI) | p Value |
| A*03 | 10 (16) | 34 (36) | 0.34 (0.14 to 0.8) | 0.007 | 33 (25) | 10 (35) | 0.6 (0.2 to 1.7) | 0.35 |
| B*27 | 4 (7) | 8 (9) | 0.7 (0.2 to 3) | 0.77 | 4 (3) | 6 (21) | 0.12 (0.02 to 0.6) | 0.002 |
| C*01 | 2 (3) | 5 (5) | 0.6 (0.06 to 3.8) | 0.7 | 3 (2) | 5 (17) | 0.11 (0.02 to 0.6) | 0.005 |
| B*15 | 3 (5) | 7 (7) | 0.6 (0.1 to 3) | 0.74 | 3 (2) | 4 (14) | 0.2 (0.02 to 0.9) | 0.02 |
| Cw*16 | 11 (18) | 6 (6) | 3.1 (1 to 11) | 0.035 | 7 (5) | 7 (24) | 0.3 (0.07 to 1.2) | 0.04 |
| C*09 | 5 (8) | 1 (1) | 8.1 (0.9 to 389) | 0.037 | 4 (3) | 1 (3) | 0.9 (0.08 to 44) | 1 |
| HLA | Chronic n=47 | Resolved n=56 | OR (95% CI) | p | Chronic n=89 | Resolved n=21 | OR (95% CI) | p |
| DRB1*01:01 | 3 (5) | 17 (18) | 0.16 (0.03 to 0.6) | 0.002 | 8 (6) | 9 (31) | 0.14 (0.04 to 0.5) | 0.001 |
| DQB1*05:01 | 8 (13) | 20 (21) | 0.4 (0.1 to 1) | 0.045 | 11 (8) | 9 (31) | 0.2 (0.06 to 0.6) | 0.003 |
| DQB1*02:01 | 18 (29) | 9 (10) | 3.2 (1.2 to 9.3) | 0.014 | 38 (28) | 2 (7) | 7 (1.5 to 66) | 0.005 |
| DRB1*03:01 | 17 (27) | 9 (10) | 2.9 (1.1 to 8.5) | 0.024 | 38 (28) | 2 (7) | 7 (1.5 to 66) | 0.005 |
| DRB1*04:01 | 9 (15) | 17 (18) | 0.5 (0.2 to 1.5) | 0.26 | 11 (8) | 5 (17) | 0.5 (0.1 to 2) | 0.18 |
| DQB1*02:02 | 14 (23) | 4 (4) | 5.4 (1.5 to 25) | 0.004 | 19 (14) | 4 (14) | 1.2 (0.3 to 5.3) | 1 |
| DR*13:01 | 9 | 0 | 0 | 0 | 11 | 2 | 1.3 (0.3 to 13.4) | |