Imputation methods for Trial 302
Abdominal pain/discomfort responder, n (%) | IBS degree-of-relief responder, n (%) | |||||
Analysis | PBO (N = 403) | LIN (N = 401) | Δ; OR (95% CI) | PBO (N = 403) | LIN (N = 401) | Δ; OR (95% CI) |
OC | 155 (38.5) | 217 (54.1) | 15.6; 1.89 (1.43, 2.51)* | 67 (16.6) | 158 (39.4) | 22.8; 3.26 (2.34, 4.53)* |
LOCF | 172 (42.7) | 246 (61.3) | 18.7; 2.15 (1.62, 2.85)* | 74 (18.4) | 174 (43.4) | 25.0; 3.39 (2.46, 4.67)* |
BOCF | 132 (32.8) | 191 (47.6) | 14.8; 1.88 (1.41, 2.51)* | 68 (16.9) | 158 (39.4) | 22.5; 3.20 (2.30, 4.44)* |
Drop-out as non-responder | 134 (33.3) | 186 (46.4) | 13.1; 1.75 (1.31, 2.33)* | 65 (16.1) | 139 (34.7) | 18.6; 2.75 (1.97, 3.84)* |
Multiple imputation approach | 177 (43.8) | 246 (61.3) | 17.5; 2.05 (1.53, 2.74)* | 70 (17.4) | 167 (41.7) | 24.3; 3.40 (2.42, 4.76)* |
↵* P < P < 0.0001; CI, confidence interval; OR, odds ratio; Δ, delta (difference between LIN and PBO)