Combination of independent polymorphisms (pairwise r2<0.1) to predict risk of gastric carcinoma
| Gene | Variant ID | Target | PAR (%) | Joint PAR (%) | Joint MAF | NNS (ltr: 1%) | NNS (ltr: 5%) |
|---|---|---|---|---|---|---|---|
| PSCA | rs2294008 | Non-cardia | 15.3 | 28.8 | 0.24 | 666 | 133 |
| PRKAA1 | rs13361707 | Non-cardia | 16.0 | ||||
| PLCE1 | rs2274223 | Asian | 11.1 | 37.1 | 0.12 | 990 | 198 |
| TGFBR2 | rs3087465 | Asian | 26.4 | ||||
| GSTP1 | rs1695 | Asian | 3.9 | ||||
| CASP8 | rs3834129 | Mixed | 19.0 | 21.3 | 0.30 | 707 | 141 |
| TNF | rs1799724 | Mixed | 2.9 | ||||
| MUC1 | rs2070803 | Diffuse | 36.5 | 51.2 | 0.05 | 424 | 22 |
| PKLR | rs3762272 | Diffuse | 23.2 |
ltr, lifetime risk; MAF, minor allele frequency (in controls); NNS, number needed to screen; PAR, population-attributable risk.