Meta-analysis results: variants with non-significant association to gastric cancer risk with a high or intermediate level of summary evidence
| Gene | Variant ID | Chr | Risk allele | Datasets | Cases | Controls | Ethnicity | sOR | LL | UL | p Value | Power | Heterogeneity | Bias | Evidence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TGFB1 | rs1800470 | 19 | C | 4 | 1011 | 1522 | Caucasian | 0.917 | 0.817 | 1.030 | 0.143 | A | A | A | High |
| PLCE1 | rs2274223 | 10 | G | 5 | 2078 | 5694 | Non-cardia | 1.067 | 0.977 | 1.165 | 0.151 | A | A | A | High |
| IL4 | rs2243250 | 5 | T | 8 | 1878 | 3098 | Mixed | 1.063 | 0.953 | 1.187 | 0.271 | A | A | A | High |
| IL1B | rs16944 | 2 | T | 22 | 1725 | 7989 | Diffuse | 1.024 | 0.944 | 1.111 | 0.568 | A | A | A | High |
| IL1B | rs1143627 | 2 | C | 14 | 1199 | 3429 | Diffuse | 1.103 | 1.000 | 1.217 | 0.050 | B | A | B | Intermediate |
| GSTM1 | Wild/null | 1 | Null | 5 | 3081 | 3322 | Non-cardia | 1.090 | 0.998 | 1.190 | 0.056 | A | A | B | Intermediate |
| IL10 | rs1800871 | 1 | T | 15 | 2756 | 5075 | Mixed | 0.903 | 0.810 | 1.006 | 0.063 | A | B | B | Intermediate |
| CD14 | rs2569190 | 5 | C | 6 | 1231 | 2408 | Non-cardia | 1.119 | 0.977 | 1.281 | 0.105 | B | B | B | Intermediate |
| GSTT1 | Wild/null | 22 | Null | 6 | 1736 | 3280 | Intestinal | 1.168 | 0.965 | 1.413 | 0.111 | B | B | A | Intermediate |
| LTA | rs909253 | 6 | G | 16 | 3197 | 6459 | Mixed | 1.072 | 0.981 | 1.172 | 0.125 | A | B | B | Intermediate |
| MIR196a2 | rs11614913 | 12 | C | 4 | 1343 | 3440 | Diffuse | 0.937 | 0.854 | 1.029 | 0.174 | B | A | A | Intermediate |
| FAS | rs2234767 | 10 | A | 7 | 1748 | 2695 | Mixed | 1.062 | 0.960 | 1.175 | 0.242 | B | A | A | Intermediate |
| FAS | rs2234767 | 10 | A | 6 | 1634 | 2235 | Asian | 1.067 | 0.957 | 1.190 | 0.242 | B | A | B | Intermediate |
| IL4 | rs2070874 | 5 | C | 4 | 1423 | 2741 | Mixed | 0.908 | 0.742 | 1.110 | 0.346 | B | B | B | Intermediate |
| PTPN11 | rs12229892 | 12 | A | 3 | 1361 | 2740 | Asian | 0.960 | 0.875 | 1.054 | 0.394 | B | A | A | Intermediate |
| CDH1 | rs16260 | 16 | A | 8 | 1585 | 3701 | Intestinal | 0.951 | 0.841 | 1.075 | 0.424 | B | A | A | Intermediate |
| KIAA0907 | rs625658 | 1 | C | 3 | 2649 | 3101 | Asian | 0.945 | 0.816 | 1.094 | 0.448 | B | B | A | Intermediate |
| IL10 | rs1800896 | 1 | G | 9 | 1880 | 3614 | Caucasian | 0.964 | 0.854 | 1.088 | 0.555 | A | B | B | Intermediate |
| MTHFR | rs1801131 | 1 | C | 13 | 3784 | 5029 | Mixed | 0.982 | 0.874 | 1.102 | 0.751 | A | B | B | Intermediate |
| XRCC1 | rs25487 | 19 | A | 16 | 3628 | 7866 | Mixed | 0.990 | 0.904 | 1.084 | 0.827 | A | B | A | Intermediate |
| RUNX3 | rs6672420 | 1 | A | 3 | 1322 | 2394 | Asian | 0.984 | 0.853 | 1.136 | 0.830 | B | B | A | Intermediate |
| OGG1 | rs1052133 | 3 | G | 14 | 2107 | 4223 | Mixed | 0.988 | 0.867 | 1.126 | 0.853 | A | B | A | Intermediate |
| ERCC2 | rs13181 | 19 | C | 8 | 1483 | 4251 | Caucasian | 1.007 | 0.922 | 1.101 | 0.876 | B | A | B | Intermediate |
Power, heterogeneity, bias: quality of evidence (A: high, B: moderate, C: weak) for three parameters (amount of evidence, heterogeneity and bias; see text for more details); evidence: overall level of summary evidence.
Chr, chromosome; LL, 95% lower level; sOR, summary OR; UL, 95% upper level.