T84 cell proteins changed by 2′-FL
| Gene ID | Ab–Ag | INR | Name |
|---|---|---|---|
| 3611 | ILK | 0.0 | integrin-linked kinase: regulates integrin-mediated signal transduction and mediates epithelial to mesenchymal transition |
| 3903 | LAIR-1 | 0.0 | leukocyte-associated immunoglobulin-like receptor 1: regulates the immune response to prevent lysis of cell recognised as self |
| 4478 | Moesin | 0.0 | cell–cell recognition and motility signalling |
| 3303 | Hsp 70 | 0.6 | heat shock 70 kDa protein 1A: stabilises proteins against aggregation and mediates folding of newly translated proteins |
| 1398 | Crk | 0.7 | v-crk sarcoma virus CT10 oncogene homologue (avian): binds tyrosine-phosphorylated proteins; attachment, membrane ruffling and motility |
| 1195 | Clk1 (Sty) | 0.7 | CDC-like kinase 1: phosphorylates serine/arginine-rich proteins during pre-mRNA nuclear processing |
| 5159 | PDGF receptor β | 1.3 | platelet-derived growth factor receptor, β polypeptide: mitogens for mesenchyme-derived cells |
| 3486 | IGFBP-3 | 1.3 | insulin-like growth factor binding protein 3: prolongs the half life of IGFs and alters their interaction with cell surface receptors |
| 5575 | PKA RI | 1.3 | cAMP-dependent protein kinase (regulatory, type I): controls regulation of metabolism, ion transport and gene transcription |
| 2237 | FEN-1 | 1.3 | flap structure-specific endonuclease 1:1 of 10 proteins essential for cell-free DNA replication |
| 4288 | Ki-67 | 1.4 | antigen identified by monoclonal antibody Ki-67: associated with cellular proliferation |
| 1294 | COL7A1 | 1.4 | Collagen (type VII, α 1): anchoring fibril between the external epithelium and the underlying stroma |
| 995 | CDC25C | 1.5 | Cell division cycle 25C: regulates cell division by directing dephosphorylation of cyclin B bound CDC2 triggering entry into mitosis |
| 3837 | Karyopherin β | 1.5 | karyopherin (importin) β 1: component of nucleocytoplasmic transport complex |
| 6595 | Brm | 1.5 | SMARCA2, similar to the brahma protein of Drosophila: helicase and ATPase activity; transcriptional activation |
| 5705 | PSMC5 | 1.5 | Proteasome, macropain 26S subunit (ATPase, 5): cleaves MHC1 peptides in ATP/ubiquitin-dependent (non-lysosomal) process |
| 5588 | PKC θ | 1.6 | protein kinase C (θ): calcium independent protein kinase activation of T cells, NF-kB and AP-1 |
| 10507 | CD100 | 1.6 | Cluster of differentiation 100: binds CD72; activate B cells and dendritic cells |
| 4842 | nNOS | 1.6 | nitric oxide synthase 1: nitric oxide release from L-arginine; mediates neurotransmission; antimicrobial and antitumor activity |
| 7157 | p53 | 1.6 | tumor protein p53: cell stress mediator activates genes of cell cycle arrest, apoptosis, senescence, DNA repair and metabolic changes |
| 9044 | BTAF1 | 1.7 | B-TATA box-binding protein-associated factor: associates with TBP (TATA box-binding protein) to form B-TFIID complex to initiate transcription of genes by RNA polymerase II |
| 51272 | BET1L | 1.7 | Bet1 Golgi vesicular membrane trafficking protein-like: targeting and fusion of retrograde transport vesicles with the Golgi complex; integrity of the Golgi complex |
| 84254 | CAMKK1 | 1.8 | calcium/calmodulin-dependent protein kinase kinase 1, alpha: calcium/calmodulin-dependent (CaM) kinase cascade |
| 6908 | TBP | 1.8 | TATA box binding protein: initiation of transcription by RNA polymerase II |
| 4830 | NME1 | 1.9 | NME/NM23 nucleoside diphosphate kinase 1: reduces mRNA transcript levels in highly metastatic cells |
| 10399 | RACK1 (GNB2L1) | 2.3 | Receptor for activated protein kinase C-1 (guanine nucleotide binding protein 2L1): multifaceted scaffolding protein; development, cell migration, central nervous system function, circadian rhythm. |
| 3710 | IP3R-3 | 2.5 | inositol 1,4,5-triphosphate receptor, type 3: exocrine secretion, energy metabolism and growth |
| 4687 | NCF1C | 3.0 | neutrophil cytosolic factor 1 (pseudogene): 47 kDa cytosolic subunit of neutrophil NADPH oxidase that produces superoxide anion. |
2′-FL, 2′-fucosyllactose; CDC, cell division cycle; INR, internally normalised ratio.