Crude and adjusted ORs, with 95% CI, for live birth in the cohort of assisted reproductive technology (ART) treatments in women with UC who had undergone surgery before infertility treatment, compared with ART treatments in women with UC who had not undergone surgery before infertility treatment; similar results for women with CD (1 January 1994 through 2013)
| UC | ||||
|---|---|---|---|---|
| Exposed cohort (embryo transfers in women with UC who had prior surgery) (N=469)* | Unexposed cohort (embryo transfers in women with UC who had no prior surgery) (N=891)* | Crude OR (95% CI) | Adjusted OR† (95% CI) | |
| Live birth | ||||
| Yes, N (%) | 89 (18.98) | 183 (20.54) | 0.92 (0.64 to 1.31) | 0.91 (0.61 to 1.36) |
| No, N (%) | 380 (81.02) | 708 (79.46) | ||
| CD | ||||
| Exposed cohort (embryo transfers in women with CD who had prior surgery) (N=355)‡ | Unexposed cohort (embryo transfers in women with CD who had no prior surgery) (N=199)‡ | Crude OR (95% CI) | Adjusted OR† (95% CI) | |
| Live birth | ||||
| Yes, N (%) | 50 (14.08) | 44 (22.11) | 0.56 (0.33 to 0.93) | 0.51 (0.29 to 0.91) |
| No, N (%) | 305 (85.92) | 155 (77.89) | ||
*Number of women in exposed UC cohort=130 and in the unexposed cohort=303. Intraclass correlation coefficient (ICC)=0.17.
†Adjusted: duration of disease (UC or CD), Charlson index, women's age, calendar year of treatment, type of treatment (IVF, ICSI, FER), cause of infertility (female factor, male factor, or mixture of factors/idiopathic). UC analyses: number of observations=1276, number of women=427; CD analyses: number of observations=499, number of women=178.
‡Number of women in exposed CD cohort=99 and in the unexposed cohort=88. Intraclass correlation coefficient (ICC)=0.11.
CD, Crohn's disease; FER, frozen-thawed embryos; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilisation; UC, ulcerative colitis.