Crude and adjusted ORs, with 95% CI, for live birth in the study cohorts of assisted reproductive technology (ART) treatments in women with UC compared with women without IBD; similar results for women with CD (1 January 1994 through 2013)
| UC | |||||
|---|---|---|---|---|---|
| Exposed cohort (embryo transfers in women with UC) (N=1360)* | Unexposed cohort (embryo transfers in women without IBD) (N=148 540)† | Crude OR (95% CI) | Adjusted OR‡ (95% CI) | Adjusted OR§ (95% CI) | |
| Live birth | |||||
| Yes, N (%) | 272 (20.00) | 35 321 (23.78) | 0.79 (0.67 to 0.92) | 0.78 (0.67 to 0.91) | 0.73 (0.58 to 0.92) |
| No, N (%) | 1088 (80.00) | 113 219 (76.22) | |||
| CD | |||||
| Exposed cohort (embryo transfers in women with CD) (N=554)* | Unexposed cohort (embryo transfers in women without IBD) (N=148 540)† | Crude OR (95% CI) | Adjusted OR‡ (95% CI) | Adjusted OR§ (95% CI) | |
| Live birth | |||||
| Yes, N (%) | 94 (16.97) | 35 321 (23.78) | 0.62 (0.48 to 0.80) | 0.61 (0.47 to 0.79) | 0.77 (0.52 to 1.14) |
| No, N (%) | 460 (83.03) | 113 219 (76.22) | |||
*Number of women in exposed UC cohort=432 and in exposed CD cohort=182. Intraclass correlation coefficient (ICC)=0.13.
†Number of women in unexposed cohort=52 489.
‡Adjusted for Charlson Index, women's age, calendar year of treatment, type of treatment (IVF, ICSI, FER), cause of infertility (female factor, male factor, or mixture of factors/idiopathic). Number of observations=137 640, number of women=52 015.
§Extended model using data from 2006, adjusted for Charlson Index, women's age, calendar year of treatment, type of treatment (IVF, ICSI, FER), cause of infertility (female factor, male factor, or mixture of factors/idiopathic), BMI, partner's age, smoking at the time of embryo transfer and alcohol. Number of observations=48 575, number of women=20 082.
BMI, body mass index; CD, Crohn's disease; FER, frozen-thawed embryos; IBD, inflammatory bowel disease; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilisation; UC, ulcerative colitis.