Viral sequence analyses and predictors of spontaneous clearance
| Clearers (95% CI) | Progressors (PV+FV) (95% CI) | p Value | |
| Number | 10 | 40 | – |
| Baseline quasispecies | 3 (2 to 5) | 4 (3 to 6) | 0.21 |
| Cumulative quasispecies (two samples taken <150 days apart) | 7 (7 to 8) | 9 (8 to 12) | 0.24 |
| Baseline Hamming distance | 0.39 (0.22 to 0.92) | 0.64 (0.36 to 2.97) | 0.38 |
| Cumulative Hamming distance (two samples taken <150 days apart) | 0.03 (0 to 0.06) | 2.045 (0.81 to 10.47) | 0.02* |
| Baseline HVR-1 dN/dS | 0 (0 to 0.325) | 0.28 (0 to 0.95) | 0.18 |
| Cumulative HVR-1 dN/dS (two samples taken <150 days apart) | 0.17 (0 to 0.35) | 1.02 (0.71 to 1.84) | 0.03* |
↵* Significant p value<0.05.
dN/dS, non-synonymous substitutions per non-synonymous site divided by synonymous substitutions per synonymous site; FV, fluctuating viraemia; HVR-1, hypervariable region-1; PV, plateau viraemia.