Responder rates for individual symptoms: (average symptom score at the last observation period)/(average symptom score at baseline) ≦0.5
| Symptom | Group | N | Responder rate (%) | p Value |
| Upper abdominal pain | Placebo | 442 | 60.7 | – |
| Acotiamide | 450 | 70.1 | 0.038 | |
| Upper abdominal discomfort | Placebo | 442 | 58.1 | – |
| Acotiamide | 450 | 64.8 | 0.080 | |
| Postprandial fullness | Placebo | 442 | 47.3 | – |
| Acotiamide | 450 | 66.5 | <0.001 | |
| Upper abdominal bloating | Placebo | 442 | 57.1 | – |
| Acotiamide | 450 | 68.9 | 0.001 | |
| Early satiation | Placebo | 442 | 56.8 | – |
| Acotiamide | 450 | 69.1 | <0.001 | |
| Nausea | Placebo | 442 | 74.4 | – |
| Acotiamide | 450 | 79.8 | 0.373 | |
| Vomiting | Placebo | 442 | 90.2 | – |
| Acotiamide | 450 | 89.3 | 1.000 | |
| Excessive belching | Placebo | 442 | 66.9 | – |
| Acotiamide | 450 | 67.7 | 0.904 |